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BMC Medical Research Methodology

Last updated on 18-03-09

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CUSUM: A tool for early feedback about performance?

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Can electronic search engines optimize screening of search results in systematic reviews: an empirical study

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Does sampling using random digit dialling really cost more than sampling from telephone directories: Debunking the myths

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Maximising response to postal questionnaires - A systematic review of randomised trials in health research

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Searching for observational studies: what does citation tracking add to PubMed? A case study in depression and coronary heart disease

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Room for improvement? A survey of the methods used in systematic reviews of adverse effects

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Sequential boundaries approach in clinical trials with unequal allocation ratios

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Stability of response characteristics of a Delphi panel: application of bootstrap data expansion

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A non-parametric framework for estimating threshold limit values

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Stability of response characteristics of a Delphi panel: application of bootstrap data expansion

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A non-parametric framework for estimating threshold limit values

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Parametric versus non-parametric statistics in the analysis of randomized trials with non-normally distributed data

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A randomised controlled trial to assess the effectiveness of offering study results as an incentive to increase response rates to postal questionnaires

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Investing in updating: how do conclusions change when Cochrane systematic reviews are updated?

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Methods for confidence interval estimation of a ratio parameter with application to location quotients

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Lack of interchangeability between visual analogue and verbal rating pain scales: a cross sectional description of pain etiology groups

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Adaptive designs based on the truncated product method

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Modeling repeated ordinal responses using a family of power transformations: application to neonatal hypothermia data

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Causal inference based on counterfactuals

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The therapeutic effect of clinical trials: understanding placebo response rates in clinical trials – A secondary analysis

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A priori postulated and real power in cluster randomized trials: mind the gap

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Which resources should be used to identify RCT/CCTs for systematic reviews: a systematic review

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A simplified search strategy for identifying randomised controlled trials for systematic reviews of health care interventions: a comparison with more exhaustive strategies

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Oblique decision trees for spatial pattern detection: optimal algorithm and application to malaria risk

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Empirical evaluation of prediction intervals for cancer incidence

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How does study quality affect the results of a diagnostic meta-analysis?

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No role for quality scores in systematic reviews of diagnostic accuracy studies

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Recruitment of ethnic minority patients to a cardiac rehabilitation trial: The Birmingham Rehabilitation Uptake Maximisation (BRUM) study

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Use of re-randomized data in meta-analysis

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Early life factors, childhood cognition and postal questionnaire response rate in middle age: the Aberdeen Children of the 1950s study

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Assessing subgroup effects with binary data: can the use of different effect measures lead to different conclusions?

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The strengths and limitations of meta-analyses based on aggregate data

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Estimating the mean and variance from the median, range, and the size of a sample

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Who wants to join preventive trials? – Experience from the Estonian Postmenopausal Hormone Therapy Trial

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Practical considerations for estimating clinical trial accrual periods: application to a multi-center effectiveness study

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Methodological bias in cluster randomised trials

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Reporting quality of randomized trials in the diet and exercise literature for weight loss

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Evaluating the role of quality assessment of primary studies in systematic reviews of cancer practice guidelines

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Effects of the search technique on the measurement of the change in quality of randomized controlled trials over time in the field of brain injury

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Effectiveness of different databases in identifying studies for systematic reviews: experience from the WHO systematic review of maternal morbidity and mortality

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Comparison of nested case-control and survival analysis methodologies for analysis of time-dependent exposure

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Factors associated with reporting multiple causes of death

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Systems validation: application to statistical programs

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Systematic reviews of epidemiology in diabetes: finding the evidence

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A suite of web applications to streamline the interdisciplinary collaboration in secondary data analyses

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A survey of statistics in three UK general practice journal

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Proportional odds ratio model for comparison of diagnostic tests in meta-analysis

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Random allocation software for parallel group randomized trials

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"Any other comments?" Open questions on questionnaires – a bane or a bonus to research?

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The fallacy of enrolling only high-risk subjects in cancer prevention trials: Is there a "free lunch"?

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Participant characteristics associated with withdrawal from a large randomized trial of spermicide effectiveness

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A systematic review of the content of critical appraisal tools

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Cluster randomised trials in the medical literature: two bibliometric surveys

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Publication bias in situ

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Assessing harmful effects in systematic Reviews

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Evaluating heterogeneity in cumulative meta-analyses

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Meta-analytic methods for pooling rates when follow-up duration varies: a case study

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WHO systematic review of maternal mortality and morbidity: methodological issues and challenges

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The Platino project: methodology of a multicenter prevalence survey of chronic obstructive pulmonary disease in major Latin American cities

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The level of non-citation of articles within a journal as a measure of quality: a comparison to the impact factor

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Incongruence between test statistics and P values in medical papers

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Comparing breast cancer mortality rates before-and-after a change in availability of screening in different regions: Extension of the paired availability design

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The rating reliability calculator

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What is the value of social values? The uselessness of assessing health-related quality of life through preference measures

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Intracluster correlation coefficients in cluster randomized trials: empirical insights into how should they be reported

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Patient recruitment to a randomized clinical trial of behavioral therapy for chronic heart failure

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The role of the clinical research coordinator – data manager – in oncology clinical trials

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Finding qualitative research: an evaluation of search strategies

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Can the caged bird sing? Reflections on the application of qualitative research methods to case study design in homeopathic medicine

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Composition of the editorial boards of leading medical education journals

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Cluster randomized trial of an active, multifaceted information dissemination intervention based on The WHO Reproductive health library to change obstetric practices: methods and design issues

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Correction: A simple method for analyzing data from a randomized trial with a missing binary outcome

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Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity

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A framework for power analysis using a structural equation modelling procedure

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Design, analysis and presentation of factorial randomised controlled trials

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The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews

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Recruitment of heterosexual couples in public health research: a study protocol

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Correction: The transitive fallacy for randomized trials: If A bests B and B bests C in separate trials, is A better than C?

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How many repeated measures in repeated measures designs? Statistical issues for comparative trials

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Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio

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Interdisciplinary research: putting the methods under the microscope

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The reporting of methods for reducing and detecting bias: an example from the WHO Misoprostol Third Stage of Labour equivalence randomised controlled trial

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How does correlation structure differ between real and fabricated data-sets?

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Imputation of a true endpoint from a surrogate: application to a cluster randomized controlled trial with partial information on the true endpoint

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A perfect correlate does not a surrogate make

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Interim analyses of data as they accumulate in laboratory experimentation

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Does anybody read "evidence-based" articles?

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Identifying null meta-analyses that are ripe for updating

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More insight into the fate of biomedical meeting abstracts: a systematic review

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Estimating the cumulative risk of false positive cancer screenings

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Randomized trials, generalizability, and meta-analysis: Graphical insights for binary outcomes

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Quantifying errors without random sampling

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A simple method for analyzing data from a randomized trial with a missing binary outcome

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Choosing a control intervention for a randomised clinical trial

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Design of Phase II cancer trials evaluating survival probabilities

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Estimation of the correlation coefficient using the Bayesian Approach and its applications for epidemiologic research

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Using observational data to estimate an upper bound on the reduction in cancer mortality due to periodic screening

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Performance of health-status scales when used selectively or within multi-scale questionnaire

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Development and evaluation of a quality score for abstracts

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A proposed architecture and method of operation for improving the protection of privacy and confidentiality in disease registers

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Sample size requirements for case-control study designs: correction

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Choosing marginal or random-effects models for longitudinal binary responses: application to self-reported disability among older persons

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Bias and heteroscedastic memory error in self-reported health behavior: an investigation using covariance structure analysis

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The transitive fallacy for randomized trials: If A bests B and B bests C in separate trials, is A better than C?

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Threshold protocol for the exchange of confidential medical data

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Statistical issues in randomized trials of cancer screening

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Meta-analysis: Neither quick nor easy

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Conducting systematic reviews of diagnostic studies: didactic guidelines

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Do multiple outcome measures require p-value adjustment?

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Publication bias in gastroenterological research – a retrospective cohort study based on abstracts submitted to a scientific meeting

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Are the Cochrane group registers comprehensive? A case study of Japanese psychiatry trials

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The probability of cost-effectiveness

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Markers for early detection of cancer: Statistical guidelines for nested case-control studies

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Meta-analysis, Simpson's paradox, and the number needed to treat

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Pooling data for Number Needed to Treat: no problems for apples

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Simpson's paradox and calculation of number needed to treat from meta-analysis

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Quality control and data-handling in multicentre studies: the case of the Multicentre Project for Tuberculosis Research

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Determinants of abstract acceptance for the Digestive Diseases Week – a cross sectional study

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Effect of paper quality on the response rate to a postal survey: A randomised controlled trial

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Sample size requirements for case-control study designs

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Updating a systematic review – what difference did it make? Case study of nicotine replacement therapy

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The Paired Availability Design for Historical Controls

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On the probability of cost-effectiveness using data from randomized clinical trials

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Incomplete evidence: the inadequacy of databases in tracing published adverse drug reactions in clinical trials

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The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study

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Assessment of the usefulness of a diagnostic test: A survey of patient preference for diagnostic techniques in the evaluation of intestinal inflammation

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Determinants of patient recruitment in a multicenter clinical trials group: trends, seasonality and the effect of large studies

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Reporting of conflicts of interest in guidelines of preventive and therapeutic interventions

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The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomized trials

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Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg

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